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The skin is the largest organ of the human body, which consists of three layers: epidermis, dermis, and subcutaneous

However, this would represent an off-label, experimental approach that falls well outside current NICE guidance or standard NHS practice, and should only ever be considered within a formal clinical trial or with robust multidisciplinary oversight, documented informed consent, and a clear monitoring plan

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PI3K/Akt and MAPK pathways have been shown to mediate downstream signaling of IGF-1 in these cells, although the relative importance of these pathways seems to differ depending on the model systems analyzed

These results as mentioned above indicate that targeting VEGF may represent an effective key factor to deter the subsequent and deleterious effect of activation of its downstream molecular pathways