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10.3390/md8102619 63 SasakiK.OthmanM

The animals received SRN-901, rapamycin, nicotinamide mononucleotide (NMN), or NR, and were followed until humane end-of-life criteria were reached

Nat Cell Biol 2022;24:13547

Since, no diffusional barrier exists in between CSF and nervous tissues interstitial space, even larger size may be able to enter up to the interstitial space by diffusion in the vicinity of CSF existence, but may not be able to be taken up by neuronal cells [43]

However, multiple metabolic gene sets, for example, oxidative phosphorylation, TCA cycle and fatty acid oxidation, were upregulated in si GLS adipocytes (Fig