glutathione peroxidase and nitric oxide The mechanisms of ROS metabolism the signaling pathways regulated Glutathione peroxidase-like nanozymes: mechanism, classification,

If ascorbic acid caused glutathione to dissociate from hematin, the spectrum of either hematin or heme should appear, but this was not the case

In renal clear cell carcinoma, disulfiram demonstrated potent antitumor activity by inhibiting NPL4, promoting oxidative stress, and inducing ferroptosis ( Furthermore, combination therapy with disulfiram and conventional chemotherapeutic agents (e.g., PARP inhibitors, sorafenib, doxorubicin) has demonstrated synergistic effects in vitro and in animal models, partially overcoming tumor resistance and improving therapeutic efficacy ( Through co-delivery via nanocarriers, precise release of disulfiram and metal ions can be achieved, enhancing drug stability and tumor targeting while reducing systemic toxicity ( 6 Conclusion and outlook As a major threat to mens health, urological cancers have shown an increasing incidence trend in recent years

doi: 10.1080/14756366.2022.2159957

Vendelbo MH, Jrgensen JO, Pedersen SB, Gormsen LC, Lund S, Schmitz O et al (2010) Exercise and fasting activate growth hormonedependent STAT5b phosphorylation

At lower concentrations or shorter exposures, classical apoptotic pathways predominate, characterized by caspase activation, chromatin condensation, and cell shrinkage without inflammation (Tabuchi et al., 2011)