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, antireductant approaches) to counteract reductive stress and its related adverse biological consequences also requires extensive future efforts

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Intra-articular injection of RIPK3 or MLKL inhibitors has been demonstrated to significantly prevent cartilage degeneration and synovial inflammation, revealing potential therapeutic targets for temporomandibular joint osteoarthritis (He et al., 2022)

Interaction with inflammatory mediators Alterations in pro- and anti-inflammatory cytokines, including interleukin (IL)-6, IL-1 and tumour necrosis factor (TNF), have been reported in populations with depression, and to a lesser extent, bipolar disorder and schizophrenia.16,17 These inflammatory cytokines are potential contributors to the underlying pathophysiology of these disorders