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Valcourt U, Alcaraz LB, Exposito JY, et al

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A close look at the results revealed that the pKaLearn predicted ionization center is not always the one provided with the Novartis set, which was predicted (not experimentally determined) by the Marvin model

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This alternative route does not appear to cause any discomfort and does not render the therapeutic agents susceptible to rapid biodegradation as seen in oral ingestion [67], for example, where molecules may prematurely react with gastric juice