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7) Terminal functionalization with polyethylene glycol

Al-Awaida, W

Bae KY, Kim SW, Shin HY, et al

NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994

The above change is associated with long-lasting decreases in the expression of the glial glutamate transporter 1 (GLT-1) and the cystine-glutamate exchange system/antiporter (system x c ) within the nucleus accumbens and/or prefrontal cortex related to downregulation of the genes encoding the latter system [6,7,8,9,10,11]
