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Several open-label and a few randomized controlled trials (RCTs) have shown that high-dose folinic acid supplementation (2 mg/kg/day) in FRAA-positive children with ASD leads to: Significant improvements in communication, social interaction, attention, and stereotypical behaviors in a substantial subset of treated children
None of the subjects smoked or had a history of intensive exercise
Growth enhancement in developing pigs
Fanaei H
