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Delving into the mechanism as to why Te cell function requires glycolysis, one study revealed that in the absence of glucose, GAPDH moonlights from its role as a glycolytic enzyme and instead binds to, and prevents the efficient translation of, IFN- mRNA (36)

In addition, there are conserved RNA-enzyme-metabolite (REM) networks, in which metabolic enzymes bind mRNA and thereby regulate expression of proteins (42)

SULTs play an important role in normal human homeostasis

(3) Controlled release system: designing nanocarriers with gradual release capabilities can ensure sustained release of disulfiram, extending the drug's duration of action in the body and enhancing efficacy (Huo et al., 2017)

W., Xu, D