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doi: 10.1016/j.jdiacomp.2016.08.025

At the molecular level, reduced NNMT activity shifts cellular methylation patterns, potentially altering epigenetic modifications via changes in SAM/S-adenosylhomocysteine (SAH) ratios

However, prior pancreatitis is NOT listed as an absolute contraindication in current FDA labeling, meaning the decision involves nuance rather than a blanket prohibition

Published 2025 Oct 1
