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Similar content being viewed by others Introduction During the process of colorectal cancer (CRC) initiation, progression, and metastasis, cancer-associated fibroblasts (CAFs), as the most abundant stromal cells in the tumor microenvironment (TME), play a crucial role in providing a scaffold and nutrients for cancer cell growth 1,2,3

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Considering the interaction between mitochondrial dysfunction and inflammation [43], we investigated whether CeO 2 @H-151 nanozymes could reduce IR-induced mitochondrial damage