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673 Prolonged PERK activation suppresses global protein synthesis, leading to synaptic failure and neuronal death 674 These disruptions are central to the pathology of neurodegeneration, as demonstrated in animal models

In addition, it has been established that they connect metabolic and adhesion/migration signalling pathways, thus altering the spreading and metastasis formation of cancer cells that usually affect them [70]

Flippo KH, Strack S

The IVD is a highly rhythmic tissue that undergoes daily changes in loading patterns, influenced by the cycles of activity and rest

Ascites is the most common clinical finding in patients with portal hypertension