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For individuals with BMI above 30 or BMI above 27 with comorbidities, FDA-approved GLP-1 receptor agonists (semaglutide, tirzepatide) have far stronger evidence and produce dramatically greater weight loss

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It is believed to promote healing in muscles, tendons, and ligaments

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Immunosenescence contributes to: Increased infection risk Slower recovery from illness Reduced vaccine responsiveness Chronic inflammation Greater susceptibility to age-related diseases At the same time , many older adults experience "inflammaging," a state of persistent low-grade inflammation that accelerates biological aging

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CJC-1295 + Ipamorelin (Growth Hormone Secretagogues) What they do: Stimulate your body to release growth hormone Marketed claims: Anti-aging Muscle growth Fat loss Better sleep Skin improvement The reality: CJC-1295 has reported serious cardiovascular events (FDA flagged this) Ipamorelin is less studied Growth hormone manipulation has known risks (cancer, organ growth) FDA status: Both banned from compounding WADA status: Prohibited (growth hormone-releasing substances) Common in: Anti-aging clinics, bodybuilding communities 4

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Mostany et al., 2013)

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