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Role of Mitochondrial Pyruvate Transport in Disease In animal studies, where the transport of pyruvate into the mitochondria via the MPC has been disrupted by gene deletion or by pharmacological inhibition, a beneficial effect is observed at the level of insulin resistance, blood glucose homeostasis, diabetes, and the development of metabolic dysfunction-associated steatohepatitis, MASH (commonly referred to as non-alcoholic steatohepatitis: NASH)

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