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Furthermore, this facilitates the secretion of proinflammatory cytokines (e.g., TNF-, IL-1, and IL-6) and attracts immune cells (e.g., macrophages, natural killer cells, and neutrophils), which accelerates stem cell injury and causes vascular endothelial dysfunction, resulting in a vicious cycle that worsens the progression of RE

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Melanin distribution inhibition via Niacinamide: Niacinamide slows melanosome transfer to the skin surface, helping prevent pigment from accumulating where you most need evening out, especially on knees, elbows, and areas prone to friction

DADS and DATS inhibited the expression of adhesion molecules, E-selectin and vascular cell adhesion molecule-1 (VCAM-1), on endothelial cell surface by reversing oxidized LDL-induced inhibition of PI3K/Akt and cAMP responsive element binding protein (CREB) signaling pathways (50)