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doi: 10.1089/ars.2007.1740

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Intervention strategies targeting the DDR-inflammation axis, such as modulating epigenetic modifications or using biologics that can indirectly ameliorate DNA repair capacity, may represent novel approaches to break the 'damage-inflammation' vicious cycle (47,148)

Senescent cells express a senescenceassociated secretory phenotype (SASP) which is characterised by the secretion of proinflammatory cytokines, ROS and MMPs, which degrade the ECM and hinder the formation of a stable tissue scaffold