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Acknowledgements Not applicable Funding The authors declare that they have no funding

114 of the participants completed 2 weeks of daily GlyNAC administration orally taken in two doses (Figure 1)

cerevisiae To examine the activity of codon-conformed A

Once the culture has been induced with IPTG, do not allow the cells to grow for extended periods of time, as cell lysis can occur and release proteases into the cytoplasm that could degrade the fusion protein

Some models take already existing PDMCTs and develop a new model from them, such as bioprinted material established from patient-derived cell lines 162 and organotypic cultures established from patient-derived xenografts 163