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Ingredient-Specific Considerations Glutathione: Oral forms are generally well tolerated at standard doses

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity

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Administration of exogenous ACTH normally stimulates the adrenal glands to produce cortisol, which can be measured to differentiate primary from secondary adrenal insufficiency