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In PD animal models, activating protective autophagy with mTOR inhibitors (such as rapamycin) while modulating microglial polarization and inhibiting inflammation with TREM2 agonists significantly improves motor function and neuropathological symptoms [315]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Banerjee R

That often points to cellular stuff happening below the surface

With either of the routes constructed, there will still be substantial harm inflicted upon the sensitive ecosystem living in the area
