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doi:10.1111/1751-7915.70072

[DOI] [PubMed] [Google Scholar] 220.Hu W, Ru Z, Xiao W, Xiong Z, Wang C, Yuan C, et al

There has even been speculation that people who naturally produce less NAD+ may be more likely to develop substance abuse disorders

The review highlights gaps in long-term safety data, especially in populations with cardiovascular or endocrine comorbidities
