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Indeed, hormone influence over BDNF expression has been demonstrated in gonadectomized female and male rats, showing decreased BDNF mRNA levels in the hippocampus that can be rescued after estradiol supplementation (Singh et al., 1995

Diet may act through multiple simultaneous mechanisms that differ depending on cell-type and brain-region

Unlike broader metabolic interventions, 5-amino-1MQ targets a specific enzymatic bottleneck in cellular NAD+ metabolism, offering researchers a precise tool for investigating the intricate relationships between methylation cycles, energy metabolism, and cellular homeostasis

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