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doi: 10.1186/s12929-018-0483-8 30 BhattAPRedinboMRBultmanSJ

Four cysteines of the membrane protein DsbB act in concert to oxidize its substrate DsbA

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demonstrated that in cisplatin-resistant ovarian cancer cells, artemisinin derivatives restored drug sensitivity by inhibiting GPX4, and combination therapy markedly reduced cell viability (285), These studies highlight the potential of chemosensitization strategies to restore drug responsiveness in resistant tumors