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Long-term safety with chronic use hasn't been established in rigorous clinical trials
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Hence, when an antioxidant can significantly reduce the level of ROS (most especially mitochondria ROS), mitigate oxidative damage, and improve mitochondrial bioenergetics of FRDA mouse models, it justifies further research in this field to comprehensively assess its therapeutic potentials in FRDA
In the light of all these aspects, non-steroidal anti-inflammatory agents such as GSH-C4, can be considered as the best topical therapy to treat scalp and non-scalp SD
