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In gastric cancer cells, MR activates BNIP3 gene expression by downregulating lncRNA PVT1 expression and interacting with DNMT3, thereby activating mitophagy and inducing cell death ( In summary, methionine restriction selectively exacerbates the oxidative stress in cancer cells by targeting their antioxidant metabolic vulnerability-particularly through disrupting glutathione synthesis-thereby ultimately inducing cell death
Acknowledgements The authors wish to thank all former and previous lab members that commented on earlier and the present versions of this review
10.1016/j.biotechadv.2014.04.004
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