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Aloe-emodin inhibits nasopharyngeal carcinoma cell (5-8F and CNE1) proliferation, migration, and promotes apoptosis by regulating Dual specificity phosphatase 1 (DUSP1), blocking ERK-1/2, AKT, and p38-MAPK pathways, and stabilizing DUSP1 via ubiquitinproteasome inhibition [508]

Given the similarity in resource use between this subset of cases and cases in MS-DRGs 799, 800, and 801, and that we believe that procedure codes describing the occlusion of the splenic artery are related to principal diagnoses in MDC 16 (typically major laceration of spleen, initial encounter), these cases would be more appropriately assigned to MS-DRGs 799, 800, and 801 in MDC 16 than their current assignment in MS-DRGs 987 through 989

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