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Description
Neurotoxicol Teratol
A recent study has demonstrated that lactate-induced acidification of the microenvironment over a period of weeks induces a metabolic adaptation of the tumor cell population, promoting -oxidation as a metabolic strategy (the CorbetFeron Effect) 71
Acenocoumarol (Sintrom) is used to slow blood clotting
Coupled with the limited bioavailability of 10% of orally-supplemented acetylcarnitine, the administration of 2 g acetylcarnitine (10 mmoles) and its incorporation in the TCA cycle would give rise to 12 mmoles ATP per day
Future studies might help in elucidating trait-dependent LAC levels
