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In vivo, mice on a high-fat diet (HFD) supplemented with TMAO exhibited greater colonic mucosal damage, reduced tight junction proteins, and elevated inflammatory markers compared to those on HFD alone, supporting the notion that TMAO induces tissue injury

Keep dry and at room temperature (59-86F [15-30]).
The researchers found that patients on L-carnitine supplementation had resolution of myalgias after five to six days

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