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These data are consistent with the in vitro activity of this IRE1 inhibitor in inhibiting GCLC, SLC7A11 and gcs-1 mRNA cleavage as shown previously (Fig

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doi: 10.1016/S0966-842X(02)02333-8 135 PeschelA.JackR

Model graphs of this in terms of contour plots (AB, AC, and BC) are shown in Figure 2 and 3D responses (AB, AC, and BC) are presented in Figure 3

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