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In addition, a subtle defect in GH secretion occurs in head-irradiated rats (Chrousos et al

Peptides are one arrow in that quiver along with lifestyle, nutrition, stress, and medical interventions

As an important antioxidant, GSH plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione S-transferases (GST) and glutathione peroxidases (GPx)

Although the precise mechanisms by which GSH regulates mitochondrial fuel oxidation are not clear, our study supports the need for additional work to investigate underlying mechanisms

Moreover, these findings hold significant implications for developing novel therapeutic strategies targeting the NRF2/ARE pathway as well as other antioxidative pathways such as p53 and HIF