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T3 and T4 are synthesized from the amino acid tyrosine thanks to the activity of sodium-iodide symporter (NIS), located on the basolateral membrane of thyrocytes, which allows the active transport of iodide into the gland, and by thyroid peroxidase (TPO), which catalyzes the oxidation of iodide to iodine that in turn is incorporated into tyrosine residues of thyroglobulin molecules to form diiodothyrosine and monoiodothyrosine in the follicular lumen [16]

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doi: 10.3389/fphar.2022.1040857 Received 09 September 2022 Accepted 02 November 2022 Published 24 November 2022 Volume 13 - 2022 Edited by Yasmina Mohammed Abd EL-Hakim, Zagazig University, Egypt Reviewed by Ali Hafez El-Far, Damanhour University, Egypt Ehab Yahya Abdelhiee, Matrouh University, Egypt Updates Copyright 2022 Algaidi, Faddladdeen, Alrefaei, Qahl, Albadawi, ALmohaimeed and Ayuob