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It tends to have a worse prognosis in those who are symptomatic or have concurrent IBD

The peptides proline-rich pentadecapeptide structure lacks conventional enzyme cleavage sites, allowing it to survive the low-pH gastric environment that destroys most peptide structures

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The assemblies of neurons that comprise the ENS are organized in circuits that control the functions of the gut in a region-specific manner and do so utilizing pattern generators modulated by sensory input as well as by reflex mechanisms