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Several GLS inhibitors have been developed, among which CB-839 is currently undergoing clinical trials as a potent, orally bioavailable GLS-selective inhibitor for the treatment of various cancers, including TNBC, NSCLC, and colon cancer (NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600)

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3.5 Network pharmacology analysis 3.5.1 PPI networks of key targets from the four Ganoderma species PPI networks of key targets were constructed for advantageous metabolites of all Ganoderma species (Figure 7 and Supplementary Table S3)

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.de Keizer PL, Packer LM, Szypowska AA, Riedl-Polderman PE, van den Broek NJ, de Bruin A