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Furthermore, western blotting results indicated that BHB addition and elimination could regulate the expression of CaMKK2 and p-CaMKK2 in HK-2 cells challenged with high glucose (Figure 5H)

doi:10.1146/annurev.neuro.30.051606.094222

Safety Profile Based on Available Data: Preclinical safety studies have not identified significant adverse effects from BPC-157 administration in animal models at doses substantially higher than those used in supplementation

The clinical symptoms of copper toxicity are severe and include severe abdominal pain, persistent vomiting, uncontrollable tremors, fever, anemia, and distinct metallic tastes

The ability of BPC-157 to naturally migrate toward areas of tissue damage further supports the micro-dosing rationale