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doi: 10.1002/humu.23552
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[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Fried RC
In cancer, special emphasis was initially placed on the degradation of type IV collagen, a major protein component of basement membranes by MMP2 and MMP9
Each cycle of freezing and thawing puts immense physical stress on the molecules, leading to aggregation and degradation
