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The biomarker ranges described here reflect optimization targets used in functional and sports medicine they are not diagnostic criteria
doi: 10.1038/s41430-019-0394-0 53 MondanelliGUgelSGrohmannUBronteV

Due to its shorter sequence, TB-500 offers enhanced metabolic stability and amenability to synthetic optimization compared to the parent protein

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The initial American College of Rheumatology (ACR) classification criteria included widespread pain and multiple specific muscular tender points
