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These mechanisms of action include the increased production of cytokines (e.g., IL-12 and IL-10), the reduced expression of tumor necrosis factor-alpha (TNF-) gene, the damage of bacterial cell membrane [61], the bactericidal and antitoxin effects, and the improvement of UTI inflammatory symptoms [62]

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doi: 10.1016/j.canlet.2008.03.009

It turns out that the toxins accumulated in the body as a result of CKD dont only increase your blood levels, they have an impact on your gut microbiome as well

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Ben-Shlomo Y, Darweesh S, Llibre-Guerra J, Marras C, San Luciano M, Tanner C