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The regulation of cytokines during OA inflammation by targeting HIF has been demonstrated by many studies, but there is still a lack of evidence for the targeted regulation of glucose metabolic pathways (especially aerobic glycolysis) by HIF in OA chondrocytes (96, 97)

In an in vitro model of H1N1 and H3N2 influenza infection of MDCK cells, quercetin demonstrated reduced cytopathic effect 48 h post-infection (69)

Glaucomatous rats presented with severe retinal damage and failed function were rats with permanent venous congestion and permanently increased intraocular pressure induced by cauterization of three of four episcleral veins (open-angle glaucoma model) [116,117,118,119,120,121]