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This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)

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This role is mediated through structured, reversible signaling circuits, primarily regulated by the PRX-Trx relay system

The Role of Glutathione in Mitochondrial Defense The primary reason to use glutathione for athletes is that it neutralizes ROS before they can destabilize the energy-producing chain