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This resistance of CRC cells to 5-FU can be linked to the activation of the PI3K/AKT signaling axis (Azwar et al

Liposomal delivery mimics the body's own cell membranes to ensure nutrients reach the bloodstream

One possible scenario is the metabolic cofactor NADPH, which is known to be required not only for lipid synthesis but also for the function of antioxidant reductases, such as glutathione reductase (GSR) and thioredoxin reductase (TXNRD) 86

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It's crucial to highlight that exceeding the recommended dosage does not necessarily translate to enhanced efficacy and may increase the likelihood of encountering adverse effects
