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[Google Scholar] 85.Xu X, Tang Q, Gao Y, Chen S, Yu Y, Qian H, et al

Osteolytic lesions cause localized bone destruction and calcium release into the bloodstream, typically presenting with severe, localized bone pain and elevated alkaline phosphatase

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The same group published the results of a smaller trial [80] with a similar population, doses, and time of treatment in 1999
