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Apart from female and male infertility (41, 42), Se deficiency was connected to heart disease (possibly fatal congestive dilated cardiomyopathy, including endemic Keshan disease), musculoskeletal and neuromuscular disorders (e.g., KashinBeck disease), thyroid function dysfunction, disrupted immune function, poor response to acute and chronic infections (including COVID-19, Coxsackie, influenza, and HIV viral infections), chronic inflammation, cancer (including colonic, gastric, pulmonary, and prostate carcinoma), and other disorders (40, 4348)

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Below are five other mechanisms of action that BPC-157 might perform

Activated IGF1R also increases Ku70 and Ku80 expression levels and thereby promotes DNA repair by NHEJ (Katayama et al., 2007) (Figure 4B)

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