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TSC-deficient cells were found to have depleted IRS-1 mRNA, an effect that is reversed by treatment with rapamycin, which inhibits unrestrained mTORC1 activation (122, 290)

It is thought that this phenomenon is due to paradoxical activation of the RAF-MEK-ERK pathway by CRAF.37,38 Spiny Follicular Hyperkeratosis In 2009, Lpez et al.39 were the first to report the appearance of keratotic follicular papules on the face of a patient 10 days after starting treatment with Sorafenib

Brevetti G, Chiariello M, Ferulano G, et al
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(1983): Carnitine
