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MR is strongly recommended as a means of prioritizing drug targets for cardiovascular research, to avoid expensive failures in phase III randomized controlled trials (RCTs) [18, 19] and to identify mechanistic targets of intervention, complementary to RCTs [19]

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The greatest benefit seems to be achieved when acetyl-L-carnitine is given using both routes

rhamnosus GG emerged as the most consistently effective, reducing plasma TMAO in both contexts