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Changes to the microbial phyla and genera observed in the 5A-1MQ-treated group switched from WD to LD could have been driven by additive, synergistic, or independent mechanisms relative to those induced by diet switch alone, which could not be determined with the current study design that lacked a group treated with 5A-1MQ and maintained on WD

When they do occur, they are typically mild and temporary

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From this level, the risk of organ complications caused by high blood pressure, such as coronary artery disease or stroke, significantly increases

Protocols usually differ in the starting dose, target dose, number of doses required, time intervals between doses, escalation of drug concentration from dose to dose, and route of administration