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doi: 10.1073/pnas.0503879102
This disease complexity presents a challenge in the treatment of epilepsy, where available anti-seizure medications (ASMs) that are tailored to the epilepsy syndrome generally only achieve a 3050% responder rate (Lscher and Klein, 2021)
In PD, impaired mitophagy due to PINK1 or Parkin mutations results in the accumulation of damaged, ROS-producing mitochondria with mtDNA leakage, triggering cGASSTING signaling and promoting dopaminergic neuron degeneration [102, 103]
[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Huang X., Liu G., Guo J., Su Z
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