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Moreover, targeting PGAM2 reversed the tolerance to androgen receptor inhibitor enzalutamide in castration resistant prostate cancer by suppressing BCL-2 pathway (Li et al., 2023)

Key takeaways: Carnitine is necessary for transporting long-chain fatty acids into mitochondria for energy production, which is particularly important in skeletal muscles and heart function
While GPX4, FSP1 overexpression, or ACSL4 deletion can protect T-cells, complete loss of ACSL4 may paradoxically dampen antitumor responses [145]

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Add Carrier Oils : Add 1-2 tablespoons of a neutral carrier oil (like jojoba oil) to balance the formula and make it suitable for spraying
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