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doi: 10.2105/AJPH.2015.302773

This enzymatic reaction consumes both nicotinamide and SAM, leading to depletion of NAD+ storesa critical coenzyme required for cellular energy production, DNA repair, and metabolic regulation

The result is reported in EU/mg on the Certificate of Analysis at cell-culture-reference acceptance limits, allowing the material to be used in sterile adipocyte and chondrocyte assays without LPS-driven confounding signals

(Comprehensive review detailing the inter-related roles of B-complex vitamins in cellular metabolism, energy production, and neurological function)

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Berger, F., Lau, C., Dahlmann, M