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The company currently has two separate phase 3 trials for severe AA, and a phase 1/2 study of a topical version of Jaktinib in mild to moderate AA, ongoing in 2023

doi: 10.1016/0006-2952(95)02436-0 10 CapuanoA.ScavoneC.RacagniG.ScaglioneF

There is increasing evidence from cross-sectional studies that some neural tube defect affected pregnancies that are not prevented by maternal folic acid supplementation and/or wheat flour folic acid fortification may result from vitamin B12 deficiency, although no randomized control trails have been conducted [5 ]

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This limitation matters because repeated-dose toxicity guidelines normally expect systematic clinical observations, body weight tracking, hematology, clinical chemistry, organ weights, and histopathological examination under a defined study design
