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Measures should be taken to ensure that the transplanted cells thrive within the hostile environment of a degenerating IVD by directly contributing to ECM synthesis and inducing a reparative shift in native cell activity via paracrine signaling or by facilitating the arrival of regenerative cells and preventing the infiltration of harmful cells

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In recent years, a minimally invasive interventional radiology procedure called prostate artery embolisation, or PAE, has begun to challenge this traditional model

Kindregan, D., Gallagher, L