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The diseases increasing severity throughout time results in substantial disability which reduces patients quality of life [1]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Ananworanich J., Lee I.T., Ensz D., Carmona L., Schaefers K., Avanesov A., Stadlbauer D., Choi A., Pucci A., McGrath S., Kuo H.H., Henry C., Chen R., Huang W., Nachbagauer R., Paris R

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