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While there have been positive reports of carnitine supplementation and enhanced exercise performance and/or improved responses to exercise, there has been a general consensus to disregard the validity of those findings as the predominate opinion is that any performance enhancements must be predicated on increased resting muscle carnitine levels

This is in contrast with TGs and hsCRP, which are important systems biomarkers, but not causal factors

However, it is exciting to note that AR113 increased hepatic FXR expression accompanied by a decrease in SREBP-1C, which in turn is involved in the regulation of hepatic bile acid and lipid metabolism and maintenance of normal hepatic function

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